O que é a doença de Alzheimer precoce - e o que a causa?

What is early-onset Alzheimer’s disease?

doença de Alzheimer is the most common cause of dementia - the name for a group of symptoms associated with the decline of brain function - in the UK. Alzheimer’s disease develops when proteins build up in the brain to form structures called plaques and tangles. This causes brain cells to die, which affects some of the things we do which are controlled by the brain, including memória, thinking, and reasoning.

Usually our memory is affected first, but sometimes different areas of the brain and the other things they do, can be affected. For some people, the first symptoms may be problems with vision or speaking, rather than memory.

Although the condition generally affects people over 65, people can develop Alzheimer’s disease at a younger age. Early onset demência, or young onset, is when people receive a diagnosis before the age of 65. Around 70,800 people with dementia in the UK are thought to have young onset dementia, and Alzheimer’s disease accounts for around 1 in 3 cases of these¹.

The symptoms of early-onset Alzheimer's vary from person to person, but the disease is progressive - meaning the symptoms get worse over time. Someone with Alzheimer’s disease may start having memory lapses, forget recent conversations, or experience mood changes, such as feeling more ansioso or agitated.

As the disease develops, memory problems will get worse and you may experience confusion and disorientation, problems with speech, insônia, mood swings and depressão. You may also experience paranoia and delusions - having beliefs that aren’t true, for example, that a relative is trying to hurt them.

In the later stages of Alzheimer's disease, the symptoms become increasingly severe and can include significant memory loss, difficulty eating and incontinence. The condition can be deeply upsetting for loved ones and the person affected may need full-time care.

Although Alzheimer’s disease is normally associated with old age, this isn’t always the cause. It's not known exactly what causes someone to develop Alzheimer's disease before the age of 65, but many researchers believe the condition may develop as the result of multiple factors.

Genética

Having a history of dementia in the family may mean someone is more at risk of developing the condition. In some cases, Alzheimer’s disease can be caused by rare genes that are inherited². In her column in the Mirror, Phillips said her mother, father, uncle and grandparents had Alzheimer’s. The presenter is a supporter of the charity Alzheimer’s Research UK and a long term campaigner for its cause.

Hilary Evans, chief executive of Alzheimer’s Research UK, said: “It takes such courage to go public with a diagnosis and Fiona knows better than most just how much good that can do. Awareness is vital and Fiona’s bravery will help many people who are going through their own dementia journeys.”

Down’s syndrome

People with Down’s syndrome and other learning disabilities are more likely to develop dementia at a younger age. Dementia in people with Down’s syndrome is usually caused by Alzheimer’s disease, but this isn’t always the case.

Heart disease and stroke

Cardiovascular diseases, such as doença cardíaca ou derrame, can increase the risk of developing Alzheimer’s disease³.

Fumar, pressão alta, colesterol alto e diabetes tipo 2 have all been linked to increased risk. Brain damage caused by alcoolismo can also increase someone’s chance of Alzheimer’s disease.

Lesões na cabeça

People who have had a severe head injury may be at higher risk of developing Alzheimer's disease⁴. However, more research is still needed to find out about this connection.

Outros fatores

Perda auditiva⁵, solidão and untreated depression⁶ are all thought to play a role in the development of dementia, but whether they cause Alzheimer's disease has yet to be fully understood. Around 1 in 5 people with Alzheimer's have depression but it is uncertain what came first so further studies in this area are needed.

1. Alzheimer’s Research UK: Young onset dementia.

2. National Institute on Ageing: Alzheimer's disease genetics fact sheet.

3. Leszek et al: The links between cardiovascular diseases and Alzheimer's disease.

4. Gottlieb et al: Head injury doubles the risk of Alzheimer's disease.

5. Jiang et al: Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort.

6. Byers et al: Depression and risk of developing dementia.